Best Natural Antidepressants

By Pina LoGiudice ND, LAc and Peter Bongiorno ND, LAc Directors of Inner Source Health

Posted on | By Pina LoGiudice ND, LAc, Peter Bongiorno ND, LAc

SAMe for Depression With Aging and Pain

SAMe stands for S-adenosylmethionine, and is a naturally occurring chemical in the body based on the amino acid methionine; it helps boost a number of neurotransmitters. SAMe also helps with healthy nerve conduction as well. It also has been shown to be helpful with patients who have arthritis and joint pain.

We love SAMe as it tends to work quickly, often lifting mood within days rather than weeks, whereas most other supplements and drugs take longer.

It has been shown to be very useful for Parkinson’s Disease patients with depression, and some studies suggest it may be most beneficial in the senior population. Other studies show it to be safe for children too, and preliminary research shows it may be safe in pregnancy, though more research is needed.

Dosing for SAMe starts slowly. Usually, we recommend a dosage of 200 mg twice daily, for the first day, then increase to 400 mg twice daily on day three, then to 400mg three times daily on day 10, and finally to the full dose of 400 mg four times daily.


There are many natural options for depression from the natural medicine world. Addressing underlying  lifestyle, diet, digestive and psychological causes is very important for long-term results. Using St. John’s wort, saffron, 5-HTP or SAMe can be a healthful and effective part of healing from depression.

Reference Source:  Dr. Peter Bongiorno’s Healing Depression: Integrated Naturopathic and Conventional Treatments. CCNM Press. Toronto, Canada. 2010. 

Article written by Pina LoGiudice ND, LAc
Co-Medical Director of Inner Source Health in New York

Article written by Peter Bongiorno ND, LAc
Co-Medical Director of Inner Source Health in New York