The Most Common Deadly Drug Interactions

At least 1.3 million Americans are at risk of premature death due to taking combinations of prescription or over-the-counter drugs that can trigger dangerous interactions. Are your meds putting your life on the line? Click here for an Herb and Supplement Interaction Checker.

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2. HCTZ Blood Pressure Medication

Approximately 16 million people in the US take diuretics such as HCTZ (hydrochlorothiazide) to reduce high blood pressure (hypertension). However, warnings about taking these drugs with other medications are frequently not reviewed with the patient by the prescriber.


RX Interaction: Heart Rhythm Medication

When HCTZ meds are mixed with heart rhythm medication, low potassium levels can result, which can lead to fatal cardiac arrhythmia (irregular heartbeat).

OTC Interaction: OTC Decongestants

These drugs decrease the effectiveness of BP meds, which means your blood pressure levels can then start to climb.

Food Interaction: Licorice

Glycyrrhizin found in black licorice root, and also used in some sweeteners and herbal teas, can also lower potassium levels, which puts your heart at risk.