What is raspberry ketone?
Raspberry ketone is an aromatic component present in raspberries and other fruits. It can also be produced synthetically in a lab.
Why has raspberry ketone been targeted for weight loss?
Scientists had previously shown that pungent compounds with similar chemical structures, such as capsaicin and synephrine, had lipolytic activity – causing fat breakdown – in rats fed a high-fat diet and in in vitro fat cells.
What did scientists do in the lab?
In one experiment, to test the effect on obesity, mice were fed a high-fat diet plus raspberry ketone for about 10 weeks. Other experiments were carried out in vitro (in test tubes, petri dishes, etc.).
What did scientists learn about fat cells?
Researchers observed that, compared to controls, raspberry ketone decreased the amount of fat in the liver and visceral adipose (abdominal fat) tissues of mice. It also significantly increased norepinephrine-induced lipolysis (the decomposition of fat) in some rat fat cells.
Researchers also tested in vitro fat cells with raspberry ketone and found that they showed greater evidence of breakdown when compared to controls.
What did scientists find out about the relationship between raspberry ketone and adiponectin?
Adiponectin is a protein used by the body to regulate metabolism. Higher levels are associated with fewer fat stores. Scientists studied the effects of raspberry ketones on in vitro fat cells and observed a higher secretion of adiponectin when compared to controls.