The Protocol Followed in the French COVID-19 Drug Combo Study

April 10, 2020

By The Dr. Oz Show Medical Unit
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The Drug Combination That Could Be a Possible Treatment for COVID-19 (4:05)

UPDATED: April 10, 2020 - 10:00 a.m. EST — Preliminary results are in from Dr. Didier Raoult's continued study of treating COVID-19 patients with hydroxychloroquine and azithromycin. This study was performed on 1,061 patients that were treated early on in their diagnosis.

Data Found:

  • 92% of patients had excellent outcomes.
  • 4% of patients had a persistent virus past 10 days.
  • 4% of patients had a poor outcome. This was defined as being in the hospital for more than 10 days.
  • 10 patients total had to go to the ICU for care.
  • 5 patients total died.

Dr. Raoult's Takeaways:

  • Found this treatment to be safe with no side effects.
  • Found the amount of hydroxychloroquine in a patient's blood correlated with his or her outcome. Therefore, people may absorb the medication differently.
  • Found some blood pressure medication correlated with poor outcomes. More investigation needs to be done.

While there is no control study for comparison, these intial results seem promising so far. The NIH is about to start a trial with 500 people.

Read official documents here:

Disclaimer: This medication regimen is still being studied. Do not take these medications without the guidance of a doctor. 

March 23, 2020 - 8:00 a.m. EST

Didier Raoult M.D, PhD is the Professor of Medicine at Universite d'Aix-Marseille and is on the frontlines of working to discover an effective treatment for COVID-19 patients. On Mar. 23, 2020's episode of The Dr. Oz Show, Dr. Oz interviewed Dr. Raoult via Zoom to find out more, including, how quickly Americans may or may not adopt the same technique. 

This is what was done in Dr. Raoult's French study and what we're going to use in our own study in America. Dr. Raoult also emphasized the importance of looking for heart issues before beginning.

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The Process:

Patients with COVID-19 infection are treated with hydroxychloroquine and azithromycin.

Plaquenil 200mg x3/day (10 days), and azithromycine 250mg for five days, twice the first day, then once for the next four days.

In order to avoid cardiac problems, an ECG is done before starting treatment, and in order to assess lung damage, a low-dose CT scan is performed.

The evaluation of the virological effect consists of a PCR before inclusion, with the quantification of the viral load on a nasopharyngeal sample, and a PCR on D5 to verify that the virus is undetectable or at levels too low to present a contagious risk.

Presentation of the study:

Paper in the International Journal of Antimicrobial Agents:

Disclaimer: This medication regimen is still being studied. Do not take these medications without the guidance of a doctor. 

Article written by The Dr. Oz Show Medical Unit