Oprah’s best friend Gayle King opens up about her struggles with weight loss and she’s taking on some of the hottest topics making headlines. Then, see how detectives race against the clock to solve a mysterious abduction, find a missing person, and stop a madman all within 72 hours.

Dr. Oz goes where he's never gone before. He's letting you eat fast-food and it's not what you expect. Learn which fast food meals you can eat under 500 calories while still enjoying the food you love.