During a tearful confession, Colleen admits her greatest fear is not only dying, but letting go of her only source of comfort: food.

Click here to watch Part 1: Dr. Oz begins his intervention with a house call. 

Click here to watch Part 3: Colleens husband and mother join the show. 

Click here to watch Part 4: After refusing medical tests for 15 years, Colleen begins treatment.

Click here to watch Part 5: Dr. Oz explains Colleens shocking test results

Click here to watch Part 6: Colleen's mentor, Ruby, promises to help her lose the weight. 

Q: I end up overeating because it makes me feel better and I never really get full. I'd like to lose weight but this makes it hard. Any suggestions?

A: Being persistently hungry can cause big trouble. So can overeating for comfort/pleasure. These two behaviors, say researchers from Baylor University's Children's Nutrition Research Center, are controlled deep within your brain by serotonin-producing neurons, but operate separately from each other — one in the hypothalamus, the other in the midbrain. They both can, however, end up fueling poor nutritional choices and obesity.

Eating for Hunger

When hunger is your motive for eating, the question is: "Does your body know when you've had enough?" Well, if you are overweight, obese or have diabetes you may develop leptin resistance and your "I am full" hormone, leptin, can't do its job. The hormone's signal to your hypothalamus is dampened, and you keep eating.

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